Scientific American recently published the article "Beyond Resveratrol: The Anti-Aging NAD Fad", an article that proposes that... ..."recent research suggests it may be possible to reverse mitochondrial decay with dietary supplements that increase cellular levels of a molecule called NAD (nicotinamide adenine dinucleotide)"... ...and also that... ..."the mitochondria in muscles of elderly mice were restored to a youthful state after just a week of injections with NMN (nicotinamide mononucleotide), a molecule that naturally occurs in cells and, like NR, boosts levels of NAD"... Since that article was published I've received an onslaught of questions about this mysterious molecule called NAD. It just so happens that a friend of mine, Thomas Ingoglia, known as one of the best NAD scientists on the planet and is also in contact with the best NAD clinicians on the planet - both with decades of experience second to none. I consider Thomas himself to be one of the most knowledgeable and frequent users of NAD I've ever met, and one of the few that has been playing around with NAD in combination with cryotherapy, blueberry extract, hyperbaric oxygen and other "biohacks" to completely turn him around from being bed-ridden sick and losing half his family in a car crash to being in the best health of his life, including crushing his first Spartan race with me last year (prior to which took high doses of NAD). Problem is, most NAD clinical researchers are all underground at the moment. The FDA doesn't look kindly at NAD supplement companies and integrative doctors, they are quite skeptical of naturopathy, and their first impulse is to turn these things and others into patentable drugs because that's the language the FDA speaks. Plus, NAD can be dangerous. Thomas even knows a guy personally (ironically, a Phd in toxicology that poisoned himself due to his own error) who hospitalized himself experimenting with the substances we're going to be talking about in this podcast episode. So you need to proceed with caution and with the formal clinical information Thomas has opened my eyes to. Along with Thomas, today's podcast features Dr. Ross Grant, Phd. Dr. Grant is perhaps the most prolific authors in the field of NAD, and he specializes on NAD in the brain. He started researching NAD research back in 1994 while being laughed at, when no one was doing NAD research. Dr. Ross Grant is Clinical Associate Professor at the University of Sydney Medical School and CEO of the Australasian Research Institute, Sydney Adventist Hospital. A biochemical pharmacologist with a Ph.D. in Neurochemistry/Neuropharmacology, Dr. Grant's research is focused on NAD - specifically the role of oxidative stress - e.g. emotional stress, diet, and exercise - and NAD metabolism on brain cell death and cellular degeneration. A secondary interest is in the effect of exposure to novel nutritional components, such as polyphenols, on human cellular response to oxidative stress, with a goal of detecting and correcting early degenerative biochemical changes associated with aging-related degenerative disease. Dr. Grant is a member of the Australian Society for Medical Research (ASMR), Australian Neuroscience society (ANS), Australian Society of Clinical & Experimental Pharmacology and Toxicology, Nutrition Society of Australia (NSA). With forty-eight articles published in peer-reviewed scientific journals, Dr. Grant is perhaps the most prolific author in the field of NAD research. In addition to Dr. Grant, we are joined by Dr. Philip Milgram, MD, from the NAD Treatment Center in San Diego, California. Dr. Milgram recovered from his own challenges with addiction and now helps other people in recovery from addiction, specifically by using NAD protocols. He trained in 1991 with Vernon Johnson, the man who coined the term "Intervention". He was certified as a Prevention Specialist by the Certifying Board of Alcohol and Drug Counselors (CCBADC) in 2001, and has three degrees in counseling from UCSD; in Counseling and Interpersonal Communication, Alcohol and Drug Counselor and Advanced Intervention. In addition to NAD Treatment Center, Dr. Milgram served as the original Medical Director of Confidential Recovery and the Pemarro Detox Center. He has also served as the Medical Consultant for The Soledad House Recovery Home for Women and ABC Recovery since they opened. He is a member of the attending staff at Scripps Memorial Hospital in La Jolla and Board Certified in Obstetrics and Gynecology. Dr. Milgram is a member of The American Society of Addiction Medicine, the California Association of Addiction Medicine, International Doctors in AA, Like-Minded Docs Addiction Medicine, The American College of Preventive Medicine, the American Society of Anti-Aging Medicine, and the American Nutraceutical Association. During our discussion, you'll discover: -An easy explanation of what exactly NAD is and what it does inside your body... -The protocol Thomas used to go from being addicted to opiates and chronically fatigued to completely healed... -How NAD can break addictions to alcohol, food, opiates and more... -The relationship between anti-aging and NAD... -The important difference between Nicotinamide Riboside vs. Nicotinamide (NMN) vs. NAD+... -The best way to "flood your body" with NAD, and why grapes and blueberries are so important when it comes to your NAD levels... -What kind of compounds, foods and lifestyle strategies enhance the effect of NAD... -How NAD can increase your time to exhaustion during exercise by over 15%... -How Thomas used NAD to enhance his performance in a Spartan race... -The best way to test your own NAD levels... -How NAD can be used in the treatment of Lyme Disease... -The best resource for people to delve more into NAD research... -And much more! Resources from this episode: -Book by Nady Braidy: NAD+ metabolism in neurodegeneration and ageing -NAD Treatment Center in San Diego, California -Nicotinamide supplements (be careful with dosage on this, as we discuss in podcast!) -Nicotinamide Riboside supplements (dosage also discussed in podcast) -Resveratrol supplements -Wild blueberry concentrate supplements Do you have questions, comments or feedback for Dr. Grant, Dr. Mingram, Thomas Ingoglia or me? Leave your thoughts at BenGreenfieldFitness.com and one of us will reply!
